Sumarexem - greinar og ritgerðir

2022

Stefansdottir SB, Jonsdottir S, Kristjansdottir H, Svansson V, Marti E, Torsteinsdottir S. Establishment of a protocol for preventive vaccination against equine insect bite hypersensitivity. Vet Immunol Immunopathol. 2022, 253:110502. https://doi.org/10.1016/j.vetimm.2022.110502

2021

Birras J, White SJ, Jonsdottir S, Novotny EN, Ziegler A, Wilson AD, Frey R, Torsteinsdottir S, Alcocer M, Marti E. First clinical expression of equine insect bite hypersensitivity is associated with co-sensitization to multiple Culicoides allergens. PLoS ONE, November 15, 2021. https://doi.org/10.1371/journal.pone.0257819

Marti E, Novotny EN, Cvitas I, Ziegler A, Wilson AD, Torsteinsdottir S, Fettelschoss-Gabriel A, Jonsdottir S. Immunopathogenesis and immunotherapy of Culicoides hypersensitivity in horses: an update. Veterinary dermatology 2021, 32:579-e156. https://doi.org/10.1111/vde.13042

Novotny EN, White S, Wilson AD, Stefánsdóttir SB, Tijhaar E, Jonsdottir S, Frey R, Reiche D, Rose H, Rhyner C, Schüpbach-Regula G, Torsteinsdottir S, Alcocer M, Marti E. Component-resolved microarray analysis of IgE sensitization profiles to Culicoides recombinant allergens in horses with insect bite hypersensitivity. Allergy 2021, 76:1147-1157. https://doi.org/10.1111/all.14556

Jonsdottir S, Torsteinsdottir S, Svansson V, Gudbrandsson J, Stefansdottir SB, Mar Bjornsson J, Runarsdottir A, Marti E. Comparison of recombinant Culicoides allergens produced in different expression systems for IgE serology of insect bite hypersensitivity in horses of different origins. Vet Immunol Immunopathol. 2021, 238:110289. https://doi: 10.1016/j.vetimm.2021.110289

2020

Raza F, Ivanek R, Freer H, Reiche D, Rose H, Torsteinsdóttir S, Svansson V, Björnsdóttir S, Wagner B. Cul o 2 specific IgG3/5 antibodies predicted Culicoides hypersensitivity in a group imported Icelandic horses. BMC Vet Res 2020, 16:283. https://doi.org/10.1186/s12917-020-02499-w

2019

Jonsdottir S, Cvitas I, Svansson V, Fettelschloss-Gabriel A, Torsteinsdottir S, Marti E. New Strategies for Prevention and Treatment of Insect Bite Hypersensitivity in Horses. Current Dermatology Reports 2019,8:303–312. https://doi.org/10.1007/s13671-019-00279-w

2018

Torsteinsdottir S, Scheidegger S, Baselgia S, Jonsdottir S, Svansson V, Björnsdottir S, Marti E. A prospective study on insect bite hypersensitivity in horses exported from Iceland into Switzerland. Acta Vet Scand 2018, 60:69. https://doi.org/10.1186/s13028-018-0425-1

Jonsdottir S., Stefansdottir S.B., Kristinarson SB., Svansson V., Bjornsson J.M., Runarsdottir A., Wagner B., Marti E., Torsteinsdottir S. Barley produced Culicoides allergens are suitable for monitoring the immune response of horses immunized with E. coli expressed allergens. Vet Immunol Immunopathol 2018, 201:32-37. https://doi.org/10.1016/j.vetimm.2018.05.005

Ziegler, A., Hamza, E., Jonsdottir, S., Rhyner,C., Wagner, B., Schuepbach-Regula, G., Torsteinsdottir, S., Svansson, V., Marti, E. Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses. Vet. Dermatol. 2018, 29:51-57. https://doi.org/10.1111/vde.12493

2017

Jonsdottir, S., Svansson,V., Stefansdóttir, S. B., Mäntylä, E., Marti, E., & Torsteinsdottir, S. IOral administration of transgenic barley expressing a Culicoides allergen induces specific antibody response. Equine Vet J. 2017, 49:512-518. https://doi.org/10.1111/evj.12655

2016

Thorsteinsdóttir L, Torsteinsdóttir S, Svansson V. Establishment and characterization of fetal equine kidney and lung cells with extended lifespan. Susceptibility to equine gammaherpesvirus infection and transfection efficiency. In Vitro Cell Dev Biol Anim. 2016, 52:872-877. https://doi.org/10.1007/s11626-016-0046-9

Jonsdottir S, Svansson V, Stefansdottir SB, Schüpbach G, Rhyner C, Marti E, Torsteinsdottir S. A preventive immunization approach against insect bite hypersensitivity: Intralymphatic injection with recombinant allergens in Alum or Alum and monophosphoryl lipid A. Vet Immunol Immunopathol. 2016, 172:14-20. https://doi.org/10.1016/j.vetimm.2016.02.017

2015

Marti E, Wang X, Jambari NN, Rhyner C, Olzhausen J, Pérez-Barea JJ, Figueredo GP, Alcocer MJ. Novel in vitro diagnosis of equine allergies using a protein array and mathematical modelling approach: A proof of concept using insect bite hypersensitivity. Vet Immunol Immunopathol. Vet Immunol Immunopathol. 2015, 167:171-7. https://doi.org/10.1016/j.vetimm.2015.06.013

Jonsdottir S, Hamza E, Janda J, Rhyner C, Meinke A, Marti E, Svansson V, Torsteinsdottir S. Developing a preventive immunization approach against insect bite hypersensitivity using recombinant allergens: A pilot study. Vet Immunol Immunopathol. 2015, 166:8-21. https://doi.org/10.1016/j.vetimm.2015.05.002

2013

Hamza E, Akdis CA, Wagner B, Steinbach F, Marti E. In vitro induction of functional allergen-specific CD4+ CD25high Treg cells in horses affected with insect bite hypersensitivity. Clin Exp Allergy. 2013, 43:889-901. https://doi.org/10.1111/cea.12131

2012

Schaffartzik A, Hamza E, Janda J, Crameri R, Marti E, Rhyner C. Equine insect bite hypersensitivity: what do we know? Vet Immunol Immunopathol. 2012, 147:113-26. https://doi.org/10.1016/j.vetimm.2012.03.017

Hamza E, Steinbach F, Marti E. CD4(+)CD25(+) T cells expressing FoxP3 in Icelandic horses affected with insect bite hypersensitivity. Vet Immunol Immunopathol. 2012, 148:139-44. https://doi.org/10.1016/j.vetimm.2011.05.033

2011

Hamza E, Gerber V, Steinbach F, Marti E. Equine CD4(+) CD25(high) T cells exhibit regulatory activity by close contact and cytokine-dependent mechanisms in vitro. Immunology 2011, 134:292-304. https://doi:10.1111/j.1365-2567.2011.03489.x

Heimann M, Janda J, Sigurdardottir OG, Svansson V, Klukowska J, von Tscharner C, Doherr M, Broström H, Andersson LS, Einarsson S, Marti E, Torsteinsdottir S. Skin-infiltrating T cells and cytokine expression in Icelandic horses affected with insect bite hypersensitivity: A possible role for regulatory T cells. Vet. Immunol. Immunopathol. 2011, 140:63-74. https://doi.org/10.1016/j.vetimm.2010.11.016

Schaffartzik, A., Marti, E., Torsteinsdottir, S.,  Mellor,P.S., Crameri, R., Rhyner, C. Selective cloning; characterization; and production of the Culicoides nubeculosus salivary gland allergen repertoire associated with equine insect bite hypersensitivity. Vet. Immunol. Immunopathol. 2011, 15:200-209. https://doi.org/10.1016/j.vetimm.2010.10.015

2010

Schaffartzik, A., Marti, E., Crameri, R., Rhyner, C. Cloning production and characterisation of antigen 5 like proteins from Simulium vittatum and Culicoides nubeculosus, the first cross-reactive allergen associated with equine insect bite hypersensitivity. Vet. Immunol. Immunopathol. 2010, 137:76-83. https://doi.org/10.1016/j.vetimm.2010.04.012

Thorsteinsdóttir L, Torfason EG, Torsteinsdóttir S, Svansson V. Isolation and partial sequencing of Equid herpesvirus 5 from a horse in Iceland. J Vet Diagn Invest. 2010, 22:420-423. https://doi.org/10.1177/104063871002200313

Hamza, E., Torsteinsdottir, S., Eydal, M., Frey, C., Mirkovitch, J., Brcic, M., Wagner, B., Wilson, A.D., Jungi, T.W. and Marti, E. Increased IL-4 and decreased regulatory cytokine production following relocation of Icelandic horses from a high to low endoparasite environment. Vet. Immunol. Immunopathol. 2010, 133:40-50. https://doi.org/10.1016/j.vetimm.2009.07.002

2009

Hellberg, W., Mellor, P.S., Torsteinsdóttir, S. and Marti E. Insect bite hypersensitivity in the horse: comparison of IgE-binding proteins in salivary gland extracts from Simulium vittatum and Culicoides nubeculosus. Vet. Immunol. Immunopathol. 2009, 132:62-7. https://doi.org/10.1016/j.vetimm.2009.09.016

Schaffartzik, A., Weichel, M., Crameri, R., Björnsdóttir Þ.S, Prisi, C., Cupp, M., Torsteinsdottir, S. and Marti E. Cloning of IgE-binding proteins from Simulium vittatum and their potential significance as allergens for equine insect bite hypersensitivity. Vet. Immunol. Immunopathol. 2009, 132:68-77. https://doi.org/10.1016/j.vetimm.2009.09.017

Russell C.L., Heesom K.J., Arthur C.J, Helps, C.R., Mellor, P.Day M.J., Torsteinsdottir, S., Björnsdóttir, T. S. and Wilson A.D. Identification and isolation of cDNA clones encoding the abundant secreted proteins in the saliva proteome of Culicoides nubeculosus. Insect Mol Biol. 2009, 18:383-393.  https://doi.org/10.1111/j.1365-2583.2009.00882.x

Svansson V., Roelse, M., Ólafsdóttir G., Thorsteinsdóttir L., Torfason E., and Torsteinsdóttir S. Immune response against equine gammaherpesvirus in Icelandic horses. Vet. Microbiol. 2009, 137:363-368. https://doi.org/10.1016/j.vetmic.2009.01.020

2008

Ólafsdóttir G, Svansson V, Ingvarsson S, Marti E and Torsteinsdóttir S. In vitro analysis of expression vectors for DNA vaccination of horses. The effect of a Kozak sequence. Acta Vet Scand. 2008, 50:44. https://doi.org/10.1186/1751-0147-50-44

Marti, E, Gerbera, V., Wilson A.D., Lavoie J.P., Horohov D., Crameri R., Lunn P., Antczak D., Björnsdóttir S., Björnsdóttir T.S., Cunningham F., Dérer M., Frey R., Hamza E., Horin P., Heimann M., Kolm-Stark G., Ólafsdóttir G., Ramery E.Russell C., Schaffartzik A., Svansson V., Torsteinsdóttir S., Wagner, B. Report of the 3rd Havemeyer Workshop on Allergic Diseases of the Horse, Holar, Iceland, June 2007. Vet. Immunol. Immunopathol. 2008, 126:351-361. https://doi.org/10.1016/j.vetimm.2008.07.008

Torfason E.G., Thorsteinsdóttir L, Torsteinsdóttir S. and Svansson V. Study of equine herpesviruses 2 and 5 in Iceland with a type-specific polymerase chain reaction. Research in Veterinary Science 2008, 85:605–611. https://doi.org/10.1016/j.rvsc.2008.01.003

Hamza, E., Wagner, B., Jungi, T.W., Mirkovitch, J. and Marti, E. Reduced incidence of insect-bite hypersensitivity in Icelandic horses is associated with a down-regulation of interleukin-4 by interleukin-10 and transforming growth factor β1. Vet. Immunol.Immunopathol. 2008, 122:65-75. https://doi.org/10.1016/j.vetimm.2007.10.018

2007

Hamza, E., Doherr, M.G., Bertoni, G., Jungi, T.W., Marti. E. Modulation of allergy in Icelandic horses is associated with a change in IL-4 producing T cells. Int. Arch Allergy Immunol. 2007, 144:325-337. https://doi:10.1159/000106459  

2006

Hellberg, W., Wilson, A.D., Mellor, P., Doherr, M.G., Torsteinsdottir, S., Zurbriggen, A., Jungi, T., Marti, E. Equine insect bite hypersensitivity: immunoblot analysis of IgE and IgG subclass responses to Culicoides nubeculosus salivary gland extract. Vet. immunol. immunopathol. 2006, 113:99-112. https://doi.org/10.1016/j.vetimm.2006.04.009

Wilson, A.D., Harwood, L., Torsteinsdottir, S., Marti, E. Production of monoclonal antibodies specific for native equine IgE and their application to monitor total serum IgE responses in horses with insect bite hypersensitivity. J. Vet. Immunol. Immunopathol. 2006, 112:156-170. https://doi.org/10.1016/j.vetimm.2006.02.003

Baselgia, S., Doherr, M.G., Mellor, P., Torsteinsdottir, S., Jermann, T., Zurbriggen, A., Jungi, T., and Marti, E. Evaluation of an in vitro sulfidoleukotriene release test for diagnosis of insect bite hypersensitivity in horses. Equine Vet J. 2006, 38:40-46. https://doi.org/10.2746/042516406775374333

Björnsdóttir, S., Sigvaldadóttir, J., Broström, H., Langvad, B., Sigurdsson, Á. Summer eczema in exported Icelandic horses: Influence of environmental and genectic factors. Acta Vet Scand 2006, 1:3. https://doi.org/10.1186/1751-0147-48-3

2004

Althaus, H., Müller, N., Busato, A., Mellor,  P.S. Torsteinsdóttir, S., and Marti, E. Cloning and sequencing of a cDNA expressing a ribosomal P0 peptide from Culicoides nubeculosus (Diptera). Vet. Immunol. Immunopathol. 2004, 99:99. https://doi.org/10.1016/j.vetimm.2004.01.011

Tuttugu og sjö hross sem bólusett hafa verið gegn sumarexemi flutt úr landi. Frétt í Bændablaðinu 2. apríl 2020

Sigríður Björnsdóttir, Sigurbjörg Þorsteinsdóttir og Vilhjálmur Svansson. Rannsóknarráð Íslands veitir veglegan styrk til lokaáfanga þróunar á bóluefni gegn sumarexemi. Bændablaðið 12. apríl 2018.

Sigríður Jónsdóttir, Þróun á bóluefni gegn sumarexemi, viðtal í Bændablaðinu 22.júní 2017

Sigríður Jónsdóttir, Þróun á bóluefni gegn sumarexemi, Próteinbólusetning í eitla með ofnæmisvökum í ónæmisglæði. Eiðfaxi desember 2014.

Sigurbjörg Þorsteinsdóttir og Vilhjálmur Svansson, Er hægt að meðhöndla sumarexem með bygggjöf? Ónæmismeðferð um slímhúð munns og meltingarfæra. Eiðfaxi desember 2013.

Sigurbjörg Þorsteinsdóttir og Vilhjálmur Svansson, Fá folöld vörn gegn sumarexemi með broddmjólkinni? Bændablaðið 13. desember 2012.

Sigurbjörg Þorsteinsdóttir og Vilhjálmur Svansson, Verður rannsóknum á sumarexemi hætt vegna fjárskorts? Eiðfaxi október 2012.

Vilhjálmur Svansson og Sigurbjörg Þorsteinsdóttir, Sumarexem smámýsofnæmi, í íslenskum hestum - meðferðarúrræði í augsýn. Bændablaðið 2. febrúar 2012.

Sigurbjörg Þorsteinsdóttir og Vilhjálmur Svansson, Sumarexem, bitfluguofnæmi í hrossum. Einangrun á ofnæmisvökum. Freyr tölubl.:11.-12. bls 34-38 (2004).

Sigurbjörg Þorsteinsdóttir og  Vihjálmur Svansson, Sumarexem í íslenskum og erlendum hestakynjum. Freyr tölubl.:10., bls 29-33 (2002).

Sigurbjörg  Þorsteinsdóttir og Vihjálmur Svansson, Sumarexem í hestum, rannsóknarátak sem miðar að því  að þróa bóluefni. Eiðfaxi-Ræktun 2,:20-23 (2001).

Sigurbjörg  Þorsteinsdóttir og Vihjálmur Svansson, Sumarexem í hestum. Freyr tölubl.:13.-14. bls 33-36 (2000).
 

Heiða Sigurðardóttir. Einangrun og tjáning ofnæmisvaka úr smámýi (Culicoides spp.) sem orsakar sumarexem í hestum. Meistararitgerð í líf- og læknavísindum við Heilbrigðisvísindasvið Háskóla Íslands. Umsjónarkennari: Sigurbjörg Þorsteinsdóttir. Leiðbeinandi: Vilhjálmur Svansson. Þriðji maður í nefnd: Valgerður Andrésdóttir. https://skemman.is/handle/1946/7838

Ragna Brá Guðnadóttir. Ónæmissvar í kjölfar bólusetningar gegn sumarexemi í hestum (Immune response following vaccination against equine insect bite hypersensitivity). Meistararitgerð í líf- og læknavísindum við Heilbrigðis-vísindasvið Háskóla Íslands. Umsjónarkennarar: Sigurbjörg Þorsteinsdóttir og Vilhjálmur Svansson. Aðrir í meistaranefnd: Stefanía P. Bjarnason. https://skemman.is/handle/1946/38765

Sara Björk Stefánsdóttir. Ónæmismeðferð gegn sumarexemi í hestum: Þróun aðferða til að tjá og hreinsa endurraðaða ofnæmisvaka í skordýrafrumukerfi og notkun þeirra við að meta árangur ónæmismeðferðar. Meistararitgerð í líf- og læknavísindum við Heilbrigðisvísindasvið Háskóla Íslands. 93 bls. http://hdl.handle.net/1946/21603

Sigríður Jónsdóttir. Development of Immunotherapy for Insect Bite Hypersensitivity in Horses. Umsjónarkennari: Sigurbjörg Þorsteinsdóttir. Leiðbeinandi: Vilhjálmur Svansson. Doktorsritgerð í líf- og læknavísindum frá Læknadeild Háskóla Íslands. Aðrir í doktorsnefnd: Eliane Marti, Einar Mäntylä og Stefán Þ. Sigurðsson. 157 bls. https://opinvisindi.is/handle/20.500.11815/297

Sigríður Jónsdóttir. Sumarexem (smámýsofnæmi) í hestum, einangrun og tjáning ofnæmisvaka í skordýrafrumum og byggi. Meistararitgerð í líf- og læknavísindum við Heilbrigðisvísindasvið Háskóla Íslands. Umsjónakennari: Sigurbjörg Þorsteinsdóttir. Leiðbeinandi: Vilhjálmur Svansson. Þriðji maður í nefnd: Einar Mäntylä, ORF. https://skemman.is/handle/1946/16951

Sæmundur Bjarni Kristínarson. Tjáning og hreinsun á ofnæmisvökum sem valda sumarexemi í hestum og samanburður á mismunandi tjáningarkerfum. Meistararitgerð í líf- og læknavísindum við Heilbrigðisvísindasvið Háskóla Íslands. Leiðbeinendur: Sigurbjörg Þorsteinsdóttir og Vilhjálmur Svansson. Aðrir í meistaranámsnefnd: Þorkell Guðjónsson. 74 bls. https://skemman.is/handle/1946/27981